Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 614-925-8 | CAS number: 69098-08-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In the key study (40M0098/934071), no mutagenic potential has been observed in the Ames Assay for the strains TA1535, TA98 and TA100. The results for the strain TA1537 were ambiguous i.e. negative and weakly positive in 5 independent experiments. A further series of Ames tests was performed within a screening program, testing different batches of 3-(4-Methoxyphenyl)-3-methoxypropionsaeuremethylester, (techn).
In a screening assay for the strain TA1537 with 3-(4-Methoxyphenyl)-3-methoxypropionsaeuremethylester (supportive study), pure (purity 97.6 %) showed no mutagenic potential of the test substance.
Further screening tests for the strain TA1537 with eight different batches of 3-(4-Methoxyphenyl)-3-methoxypropionsaeuremethylester, (techn.; approx. 60%) showed no mutagenic potential, as well as the screening tests for the strain TA98 with two out of the eight different batches.
Taking into account all the results of the key study, the supportive study (with the pure test substance) and the additional evidence from further screening studies (with the different batches of the test substance, techn.) it was concluded, that 3-(4-Methoxyphenyl)-3-methoxypropionsaeuremethylester was not mutagenic in a bacterial mutagenicity test.
Endpoint Conclusion:
Justification for classification or non-classification
The present data on genetic toxicity do not fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC and therefore, a non-classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
