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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Method: BASF-Test
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
110-87-2
IUPAC Name:
110-87-2

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Firma WIGA, Sulzfeld, Germany
- Weight at study initiation: 200 +/- 30 g
- Diet (e.g. ad libitum): ad libitum (Herilan MRH Fa. H. Eggersmann KG, Rinteln/Weser)
- Water (e.g. ad libitum): ad libitum (tap water)

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
yes
Remarks:
GC
Duration of exposure:
4 h
Concentrations:
analytical determined: 10.7 mg/l
nominal: 11.7 mg/l
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 10.7 mg/L air
Exp. duration:
4 h
Remarks on result:
other: highest concentration tested
Mortality:
no mortality was observed
Clinical signs:
other: accerlerated respiration, eyelid closure
Body weight:
no abnormalities were observed
Gross pathology:
no abnormalities were ovserved

Applicant's summary and conclusion

Conclusions:
3,4-dihydrpyran showed no toxic effects to rats after inhaltation (4 hrs) of 10.7 mg/kg bw.
Executive summary:

The acute toxicity after inhalation was investigated in a study performed with rats. Rats were exposed to air enriched with 3,4 -dihydropyran for 4 hours in a whole body inhalation chamber. Since no mortality was observed, the test substance needs not to be classified.