Registration Dossier
Registration Dossier
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EC number: 203-810-4 | CAS number: 110-87-2
Toxicity to terrestrial plants
Administrative data
- Endpoint:
- toxicity to terrestrial plants: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative effects of heterocyclic compounds on inhibition of lettuce fruit germination
- Author:
- Reynolds T
- Year:
- 1 989
- Bibliographic source:
- J. Exp. Bot.40(212): 391-404
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Germination tests were carried out for a period of 3 days with Lactuca sativa L. cv. Great Lakes fruits on agar at 30 °C in plastic containers sealed with snap-on lids. Inhibitory activity was expressed as the mol/m³ concentration of the compound producing 50 % inhibition at the given temperature.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,4-dihydro-2H-pyran
- EC Number:
- 203-810-4
- EC Name:
- 3,4-dihydro-2H-pyran
- Cas Number:
- 110-87-2
- Molecular formula:
- C5H8O
- IUPAC Name:
- 3,4-dihydro-2H-pyran
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- not specified
Test organisms
- Species:
- Lactuca sativa
- Plant group:
- Dicotyledonae (dicots)
Study design
- Test type:
- other: Effects on germination
- Total exposure duration:
- 3 d
Results and discussion
Effect concentrationsopen allclose all
- Species:
- Lactuca sativa
- Duration:
- 3 d
- Dose descriptor:
- EC50
- Effect conc.:
- 5.5 other: mol/m³
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- germination
- Remarks on result:
- other: ± 0.8 mol/m³
- Species:
- Lactuca sativa
- Duration:
- 3 d
- Dose descriptor:
- EC50
- Effect conc.:
- 693.99 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- germination
Any other information on results incl. tables
To use this result for the derivation of the PNECsoil, the EC50 -value has to be related to mg/kg soil dw. Since the amount of agar in the test was with 0.5% negligiable, the EC50 of 462.66 mg/L was related to mg/kg water and multiplicated with the factor of 1.5 (standard soil density) to get mg/kg soil dw.
Applicant's summary and conclusion
- Executive summary:
Acute toxicity to the commonly used lettuce Lactuca sativa was investigated in a non-GLP non-guideline approach by Reynolds (1989), Seed germination and root elongation were measured using an agar plate on which the plant was sowed. After 3 days an EC50 of 693.99 mg/kg soil dw was estimated for the endpoint germination related to the nominal concentration.
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