Glutaric anhydride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

This study does not conform to the standard guideline for an inhalation study, there is no estimation of the actual test concentration applied - rather a fixed amount of test compound was used to produce a saturated air concentration. The study duration was only 6 hours during which the animals were exposed to the atmosphere. No post exposure period.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Sprague-Dawley albino rats, weighing between 200 and 300 g, are exposed to substantially saturated vapor for 6 hours. The vapor is produced by enclosing approximately 100 g of the test material in a sealed 100 to 151-liter animal chamber for approximately 18 hours (static conditions). A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapor. Oxygen is added, as needed, for static exposures to maintain a chamber oxygen content of approximately 20%. If deaths occur, exposure times are varied to determine an LT50. Five males and 5 females are included for each exposure period.

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Glutaric anhydride

EC Number:

203-593-6

EC Name:

Glutaric anhydride

Cas Number:

108-55-4

Molecular formula:

C5H6O3

IUPAC Name:

glutaric anhydride

Test material form:

solid: crystalline

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

6 h

Concentrations:

Not given

No. of animals per sex per dose:

5 per sex, one dose used

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: LT50 (lethal time for 50% of animals)

Effect level:

> 6 other: Hours

Exp. duration:

6 h

Any other information on results incl. tables

Exposure to a statically-generated, substantially saturated vapor produced no deaths of 5 male or 5 female rats during or following. the 6-hour test. There were no signs of toxicity and necropsy revealed no remarkable gross lesions.