Registration Dossier
Registration Dossier
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EC number: 205-457-1 | CAS number: 141-10-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs
- Author:
- Ford RA et al.
- Year:
- 1 988
- Bibliographic source:
- Food Chem. Toxicol. 26 (4), 311-312
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- 6,10-dimethylundeca-3,5,9-trien-2-one
- EC Number:
- 205-457-1
- EC Name:
- 6,10-dimethylundeca-3,5,9-trien-2-one
- Cas Number:
- 141-10-6
- Molecular formula:
- C13H20O
- IUPAC Name:
- 6,10-dimethylundeca-3,5,9-trien-2-one
- Details on test material:
- - Lot/batch No.: 78-8-FIRM R
Constituent 1
Method
- Type of population:
- other: inmates
- Subjects:
- - Number of subjects exposed: 33
- Sex: male
- Age: 18+ - Clinical history:
- - healthy
- Controls:
- - Additional Sodium Lauryl Sulfate controls were placed on the left and petrolatum on the right site of the forearm
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test
ADMINISTRATION
- Type of application: occlusive
- Site: volar aspects of the forearms, patch sites were pretreated for 24 hours with 5% aqueous Sodium Lauryl Sulfate under occlusion for the initial patch only
- Vehicle / solvent: petrolatum
- Concentrations: 8%
- Testing/scoring schedule:
Application5 alternate day 48 hour periods; Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours; Challenge applications were preceded by 30 minute applications of 2% aqueous Sodium Lauryl Sulfate under occlusion on the left side and without Sodium Lauryl Sulfate treatment on the right
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 1/33
- Number of subjects with negative reactions: 32/33
Positive recation was not possible to confirm by further patch tests or a biopsy
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
