Registration Dossier
Registration Dossier
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EC number: 205-451-9 | CAS number: 141-05-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- in or before 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Esters
- Author:
- Fassett DW
- Year:
- 1 963
- Bibliographic source:
- In: Industrial Hygiene and Toxicology, 2nd Ed. Edited by Patty FA, Vol II, pa. 1895, Interscience Publishers, New York
Materials and methods
- Principles of method if other than guideline:
- no guideline stated
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Diethyl maleate
- EC Number:
- 205-451-9
- EC Name:
- Diethyl maleate
- Cas Number:
- 141-05-9
- Molecular formula:
- C8H12O4
- IUPAC Name:
- diethyl (Z)-but-2-enedioate
- Details on test material:
- no details on test material available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 200 mg/kg bw
- Based on:
- not specified
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50, oral of the test material was >3200 mg/kg body weight. No classification is therefored required.
- Executive summary:
The oral LD50 tested in rats, with the test material was >3200 mg/kg body weight. No classification is therefored required.
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