Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 442-600-9 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The sensitisation potential of H7134 was assessed in two guideline studies (OECD 406: Skin sensitisation) with the use of the Buehler test and performed with female Dunkin-Hartley guinea pigs (Johnson IR (2001e); Johnson IR (2001f)). An initial induction phase was followed by a secondary challenge phase. The first study gave an ambiguous result, due to positive responses observed in the control animals at all doses tested. Therefore, a second study was performed. In this second study the test substance exerted moderate skin sensitisation effects in the 40% of the animals tested, whilst such effects were not detected in the control animals. The sensitivity of the system was confirmed by the positive control.
Migrated from Short description of key information:
The sensitisation potential of H7134 was ascertained in two studies. While the results of the first study were difficult to interpret, the second study resulted in clear positive sensitisation responses.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No information available on respiratory sensitisation of the substance.
Justification for classification or non-classification
According to the Regulation (EC) 1272/2008 a response of at least 15 % of the animals is considered positive for a non-adjuvant guinea pig test method like the Buehler test; hence, since HiTEC 7134 gave a net response of 40% it shall be classified as a skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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