Registration Dossier
Registration Dossier
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EC number: 211-425-8 | CAS number: 644-97-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1972
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary Information from a study in rabbits, performed in 1972, taken from public TSCA8e submission file
Data source
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloro(phenyl)phosphine
- EC Number:
- 211-425-8
- EC Name:
- Dichloro(phenyl)phosphine
- Cas Number:
- 644-97-3
- Molecular formula:
- C6H5Cl2P
- IUPAC Name:
- dichloro(phenyl)phosphine
- Details on test material:
- clear colourless liquid
Benzene Phosphorous Dichloride
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- indicated, but illegible
- Duration of treatment / exposure:
- 24h
- Observation period:
- 48h (reading at 4h, 24h and 48h)
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4h, 24h, 48h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4h, 24h 48h
- Score:
- 4
- Max. score:
- 4
Any other information on results incl. tables
There is a hand-written note that probably reads as "rabbits phonate instantanously XXXXX taken place" (XXXX = Word not illigible)
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Executive summary:
Based on the highly acidic pH, the substance is considered as corrosive to skin.
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