Registration Dossier
Registration Dossier
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EC number: 211-425-8 | CAS number: 644-97-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source, given as valid without restrictions in the US HPV summary
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute toxicity
- Author:
- US EPA
- Year:
- 1 997
- Bibliographic source:
- http://iaspub.epa.gov/oppthpv/Public_Search.PublicTabs?SECTION=1&epco...
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dichloro(phenyl)phosphine
- EC Number:
- 211-425-8
- EC Name:
- Dichloro(phenyl)phosphine
- Cas Number:
- 644-97-3
- Molecular formula:
- C6H5Cl2P
- IUPAC Name:
- dichloro(phenyl)phosphine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk: ApfsD (Wistar-derived)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Remarks on result:
- other: No mortality at 500 mg/kg bw. In the range-finder study, one animal was given 2000 mg/kg bw and this animal died.
- Mortality:
- yes (2000 mg/kg bw, 1/1 animal)
Any other information on results incl. tables
According to the study report, there were no signs of evident toxicity and all animals showed an overall body weight gain during the study. Two male animals had mottled lungs and froth in the trachea at necropsy which may be treatment related. The necropsy data, however, supports the conclusion that the administered BPD was hydrolyzed in vivo, presumably to the relatively strong acids BPA and BPD and that these compounds caused their characteristic effect - gastrointestinal bleeding. The single animal dosed with 2000 mg/kg died on the first day and the necropsy comment was, "stomach and intestine contents dark (black). In addition, all 5 males dosed at 500 mg/kg where noted to have "slight" scores for "activity decreased" on the day of dosing. This is consistent with the interpretation that the hydrolysis products produced gastrointestinal irritation and possible distress. The absence of gastrointestinal findings at necropsy in the 500 mg/kg animals may be attributed to healing.
Applicant's summary and conclusion
- Conclusions:
- The LD50 is considered to be lower than 2000 mg/kg bw, but higher than 500 mg/kg bw.
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