Registration Dossier
Registration Dossier
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EC number: 210-800-3 | CAS number: 623-51-8
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is shown in the attached document as well (QPRF). QSAR model reporting format is shown in the QMRF file attached.
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- VEGA in silico platform
- Year:
- 2 022
- Bibliographic source:
- Fish Acute (LC50) Toxicity classification (SarPy/IRFMN) 1.0.3
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Test material
- Reference substance name:
- Ethyl mercaptoacetate
- EC Number:
- 210-800-3
- EC Name:
- Ethyl mercaptoacetate
- Cas Number:
- 623-51-8
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- ethyl 2-sulfanylacetate
Constituent 1
- Specific details on test material used for the study:
- O=C(OCC)CS
Test organisms
- Test organisms (species):
- other: Fish
Results and discussion
Effect concentrations
- Dose descriptor:
- LC50
- Effect conc.:
- >= 1 - <= 10 mg/L
- Conc. based on:
- test mat.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
The prediction was deemed to be not reliable on the basis of the parameters listed above. The molecule does not fall into the applicability domain of the model.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- The LC50 of the substance was predicted to fall between 1 and 10 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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