Cyclohexanecarboxylic acid, 1-[[2-(2,5-dimethylphenyl)acetyl]amino]-4-methoxy-, methyl ester, cis-

Guidance on Safe Use

First-aid measures

Relating to solution of the substance in DMAC.

- Inhalation

Move to fresh air. Keep patient warm and at rest. Call a physician or poison control center immediately.

- Skin contact

Wash off thoroughly with plenty of soap and water, if available with polyethyleneglycol 400, subsequently rinse with water. If symptoms persist, call a physician.

- Eye contact

Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Get medical attention if irritation develops and persists.

- Ingestion

Rinse mouth. Do NOT induce vomiting. Call a physician or poison control center immediately.

- Treatment

Treat symptomatically.

In case of ingestion gastric lavage should be considered in cases of significant ingestions only within the first 2 hours. However, the application of activated charcoal and sodium sulphate is always advisable.

Fire-fighting measures

Relating to solution of the substance in DMAC.

 

- Suitable extinguishing media

Water spray, Carbon dioxide (CO2), Foam, Sand

 

- Specific hazards during fire fighting

In the event of fire the following may be released: Hydrogen cyanide (hydrocyanic acid), Carbon monoxide (CO), nitrogen oxides (NOx)

 

- Advice for firefighters:

Special protective equipment for fire-fighters: In the event of fire and/or explosion do not breathe fumes. In the event of fire, wear self-contained breathing apparatus.

Further information: Contain the spread of the fire-fighting media. Do not allow run-off from fire fighting to enter drains or water courses

Accidental release measures

Relating to solution of the substance in DMAC.

 

- Personal precautions

Avoid contact with spilled product or contaminated surfaces. Use personal protective equipment. Remove all sources of ignition.

 

- Environmental precautions

Do not allow to get into surface water, drains and ground water.

 

- Methods for cleaning up

Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Clean contaminated floors and objects thoroughly, observing environmental regulations. Keep in suitable, closed containers for disposal.

Handling and storage

Relating to solution of the substance in DMAC.

 

This substance is handled under Strictly Controlled Conditions in accordance with  REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4).  Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

 

- Advice on safe handling

Use only in area provided with appropriate exhaust ventilation. Advice on protection against fire and explosion. Keep away from heat and sources of ignition.

Take measures to prevent the build up of electrostatic charge.

 

Avoid contact with skin, eyes and clothing. Keep working clothes separately. Wash hands immediately after work, if necessary take a shower. Remove soiled clothing immediately and clean thoroughly before using again. Garments that cannot be cleaned must be destroyed (burnt).

 

- Storage

Requirements for storage areas and containers:

Store in original container. Keep containers tightly closed in a dry, cool and well-ventilated place. Store in a place accessible by authorized persons only.

 

Advice on common storage:

Keep away from food, drink and animal feedingstuffs.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 1993

Shipping information

Proper shipping name and description:

FLAMMABLE LIQUID, N.O.S.

Chemical name:

CHLOROBENZENE SOLUTION

Language:

English

Class or division:

Class 3: Flammable liquids

Packing group:

Packing group III: Substances presenting low danger

Labels:

Packaging 3, Bulk 3, Haz ID 30 EAC 3Y

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN 1993

Shipping information

Proper shipping name and description:

FLAMMABLE LIQUID, N.O.S.

Chemical name:

CHLOROBENZENE SOLUTION

Language:

English

Class or division:

Class 3: Flammable liquids

Packing group:

Packing group III: Substances presenting low danger

Labels:

Packaging 3, Bulk 3, Haz ID 30

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN 1993

Shipping information

Proper shipping name and description:

FLAMMABLE LIQUID, N.O.S.

Chemical name:

CHLOROBENZENE SOLUTION

Language:

English

Class or division:

Class 3: Flammable liquids

Packing group:

Packing group III: Substances presenting low danger

EmS code:

F-E

S-E

Labels:

Packaging 3, Bulk 3

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN 1993

Shipping information

Proper shipping name and description:

FLAMMABLE LIQUID, N.O.S.

Chemical name:

CHLOROBENZENE SOLUTION

Language:

English

Class or division:

Class 3: Flammable liquids

Packing group:

Packing group III: Substances presenting low danger

Labels:

Packaging 3

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

Transport of the substance in a solvent

Exposure controls / personal protection

Relating to solution of the substance in a DMAC.

 

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4).  Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

 

 

Respiratory protection:

If product is handled while not enclosed, and if contact may occur:
Wear respirator with an organic vapours and gas filter mask (protection factor 10) conforming to EN140 type A or equivalent.
Respiratory protection should only be used to control residual risk of short duration activities, when all reasonably practicable steps have been taken to reduce exposure at source e.g. containment and/or local extract ventilation. Always follow respirator manufacturer's instructions regarding wearing and maintenance.

 

Hand protection:

Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. Also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion, and the contact time.
Wash gloves when contaminated. Dispose of when contaminated inside, when perforated or when contamination on the outside cannot be removed. Wash hands frequently and always before eating, drinking, smoking or using the toilet.

 

Eye protection:

Wear goggles (conforming to EN166, Field of Use = 5 or equivalent).

 

Skin and body protection:

Wear standard coveralls and Category 3 Type 6 suit.
If there is a risk of significant exposure, consider a higher protective type suit.
Wear two layers of clothing wherever possible. Polyester/cotton or cotton overalls should be worn under chemical protection suit and should be professionally laundered frequently.
If chemical protection suit is splashed, sprayed or significantly contaminated, decontaminate as far as possible, then carefully remove and dispose of as advised by manufacturer.

 

General protective measures
If product is handled while not enclosed, and if contact may occur: Complete suit protecting against chemicals

Stability and reactivity

Relating to solution of the substance in DMAC.

 

Reactivity: No hazardous reactions when stored and handled according to prescribed instructions.

Chemical stability: Stable under recommended storage conditions.

Possibility of hazardous reactions:  No hazardous reactions when stored and handled according to prescribed instructions.

Conditions to avoid: Extremes of temperature and direct sunlight.
Incompatible materials: Store only in the original container.

Hazardous decomposition products: 
No decomposition products expected under normal conditions of use.

Disposal considerations

The substance is handled as an intermediate under under strictly controlled conditions.

During the whole life cycle of the substance all necessary measures in accordance to Art. 18(4) of Regulation (EC) No 1907/2006 are undertaken. 

Dispose in accordance with current regulations and, if necessary, after consultation with the site operator and/or with the responsible authority, the product may be taken to a waste disposal site or incineration plant.