Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-610-9 | CAS number: 122795-41-9
Endpoint summary
Administrative data
Description of key information
Skin irritation: Not irritating based on an OECD TG 404 test.
Eye irritation: Not irritating based on an OECD TG 405 test.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
The irritant effects of Neoproxen to rabbit skin was assessed in a GLP study according to OECD Guideline No. 404. Well-defined erythema accompanied by very slight to slight oedema was observed in all three animals after removal of the dressings. The reactions resolved slowly and the skins were normal by Day 9 of the Study.
Eye irritation:
The irritant effects of Neoproxen to the rabbit eye was assessed in a GLP study according to OECD Guideline No. 405. Slight effects on conjunctivae were observed in all animals only at day 1.
Justification for classification or non-classification
Based on the results of the available in vivo skin and eye studies, the substance does not need to be classified for skin and eye irritation according to EU CLP (EC 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
