Registration Dossier
Registration Dossier
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EC number: 403-610-9 | CAS number: 122795-41-9
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: OECD TG 401: LD50 2100 mg/kg bw.
Acute dermal toxicity: OECD TG 402: LD50 >2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 100 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
Using OECD TG 401, the acute median lethal oral dose (LD50) and their 95% confidence limits to rats of Neoproxen was 2.1 g/kg bodyweight (1.7 -2.7): males and females combined.
Acute dermal toxicity
The acute dermal toxicity of Neoproxen was determined in a GLP study according to OECD Guideline 402. There were no deaths or signs of systemic toxicity or dermal irritation. No abnormalities were noted at necropsy. The acute lethal dermal dose to rats of Neoproxen was found to be greater than 2.0 g/kg bodyweight.
Justification for classification or non-classification
The substance does not have to be classified for Acute oral and Acute dermal toxicity according to EU CLP (EC No. 1272/2008 and its amendments).
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