Registration Dossier
Registration Dossier
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EC number: 222-158-1 | CAS number: 3373-59-9
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-19 to 2013-11-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Principles of method if other than guideline:
- NA
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- capillary method
Test material
- Reference substance name:
- Methyl L-threoninate
- EC Number:
- 222-158-1
- EC Name:
- Methyl L-threoninate
- Cas Number:
- 3373-59-9
- Molecular formula:
- C5H11NO3
- IUPAC Name:
- Methyl (2S,3R)-2-amino-3-hydroxy-butanoate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): L-threonine methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.8%
- Lot/batch No.: X5UYC99
- Expiration date of the lot/batch: July 2014
- Storage condition of test material: Frozen
Constituent 1
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- > 56 - < 67 °C
- Decomposition:
- yes
- Decomp. temp.:
- > 124 °C
- Sublimation:
- no
Any other information on results incl. tables
The results of duplicate melting point determinations of L-TME at different melting stages (A-E) were as follows:
Sample I: 56.0 (A); 62.5 (B); 65.5 (C); 66.5 (D); 67.0 (E)
Sample II: 56.0 (A); 62.5 (B); 65.0 (C); 66.0 (D); 67.0 (E)
Applicant's summary and conclusion
- Conclusions:
- L-TME melts over the range 56 to 67°C.
- Executive summary:
The melting point of L-TME was measured in accordance to OECD 102 using the capillary method. From duplicate melting point determinations, it was concluded that L-TME melts over the range 56 to 67°C.
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