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EC number: 607-081-7 | CAS number: 224586-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 January to 03 February 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(butan-2-yloxy)-3,5-dimethoxybenzaldehyde
- EC Number:
- 607-081-7
- Cas Number:
- 224586-49-6
- Molecular formula:
- C13H18O4
- IUPAC Name:
- 4-(butan-2-yloxy)-3,5-dimethoxybenzaldehyde
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): v175023
- Physical state: brown liquid
- Analytical purity: 99.05%
- Lot/batch No.: v175023/P8B
- Expiration date of the lot/batch: 15 Dec 2004
- Storage condition of test material: at room temperature protected from light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sultzfeld, Germany
- Age at study initiation: ca 8 weeks
- Weight at study initiation: 159-195 g
- Fasting period before study: 20 hours (+ 3-4 hours after administration of the substance)
- Housing: 3 animals in Macrolon cages (type IV height 18 cm) with purified sawdust bedding material
- Diet: pelleted laboratory animal diet (Altromin (VRF1), Lage, Germany) ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.6-20.8°C
- Humidity (%): 34-80%
- Air changes (per hr): ca. 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.744 mL/kg (2000 mg/kg bw); 0.262 ml/kg (300 mg/kg bw)
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: not indicated - Doses:
- 2000 mg/kg bw and 300 mg/kg bw
- No. of animals per sex per dose:
- 3 females/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: clinical signs on periodic intervals during day 1 and daily thereafter
- Frequency of weighing: on day 1 (before treatment), 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopy - Statistics:
- NA
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2 females at 2000 mg/kg bw on day 1
none at the two trials at 300 mg/kg bw - Clinical signs:
- other: At 2000 mg/kg bw tremor, lethargy, hunched posture, ventro-lateral recumbency, piloerection, shallow respiration, ptosis, flat gait, uncoordinated movements in females that died tremor, lethargy, hunched posture, shallow respiration, piloerection, ptosis,
- Gross pathology:
- no findings in survivors
abnormalities of the glanduar mucosa (red foci, crateriform retraction) in animals that died
Any other information on results incl. tables
It is not clear from the report whether the animals at 2000 mg/kg bw were found dead or were killed in extremis.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the substance is between 300 and 2000 mg/kg bw
- Executive summary:
The substance was tested with the acute toxic class method in female rats (3/group) treated at 2000 mg/kg bw and 300 mg/kg bw. In the first trial at 2000 mg/kg bw 2 females died on day 1 (showing abnormalities of the glandular mucosis). In the second and third trial no mortality was observed. Clinical signs in surviving animals consisted of among others of tremor, hunched posture and/or uncoordinated movements (day 1 and 2). No effects on bodyweight and no macroscopic abnormalites were found in surviving animals. The LD50 is between 300 and 2000 mg/kg bw.
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