phosphonic acid, [2-(4-aminophenyl)-1-hydroxyethylidene]bis-, monosodium salt

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The study was conducted between 12 September 2018 and 17 November 2018.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

air comparison pycnometer (for solids)

Test material

Test material information

Constituent 1

Reference substance name:

phosphonic acid, [2-(4-aminophenyl)-1-hydroxyethylidene]bis-, monosodium salt

EC Number:

828-215-2

Cas Number:

172796-84-8

Molecular formula:

C8H12NO7P2Na

IUPAC Name:

phosphonic acid, [2-(4-aminophenyl)-1-hydroxyethylidene]bis-, monosodium salt

impurity 1

Reference substance name:

4-aminophenylacetic acid

EC Number:

214-828-7

EC Name:

4-aminophenylacetic acid

Cas Number:

1197-55-3

Molecular formula:

C8H9NO2

IUPAC Name:

4-aminophenylacetic acid

impurity 2

Reference substance name:

EBP dimer

Molecular formula:

C16H22N2O12P4

IUPAC Name:

EBP dimer

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

Identification: Phosphonic acid, [2-(4-aminophenyl)-1-hydroxyethylidene]bis-, monosodium salt (“EBP”)
Appearance/Physical state: Beige colored powder
Batch: CHPC071917EBP
Purity: >90%
Expiry date: 01 July 2019
Storage conditions: Room temperature in the dark

Results and discussion

Density

Key result

Type:

relative density

Density:

1.77 other: dimensionless

Temp.:

20 °C

Any other information on results incl. tables

Calibration

The pressure readings and the calculated volume for the reference and sample cells are shown in the following table:

Determination	P1 (psig)	P2 (psig)	P3 (psig)	P4 (psig)	Reference Cell Volume (cm^3)	Sample Cell Volume (cm^3)
1	17.329	6.561	17.859	8.850	90.749	148.938
2	17.334	6.565	17.911	8.876	90.865	149.052
3	18.245	6.914	18.037	8.943	90.936	149.031

Mean reference cell volume   :          90.850 cm³
Mean sample cell volume      :          149.007 cm³

As the reference cell volume and sample cell volume were within the defined tolerance (90.953 ± 1.0 cm³and 149.225 ± 1.0 cm³for the reference and sample cell volumes respectively), the gas comparison pycnometer was therefore considered acceptable for use.

 Sample

The pressure readings, calculated volumes and density values obtained for the test item are shown in the following table:

Determination	Replicate	P1(sample) (psig)	P2(sample) (psig)	Volume (cm^3)	Density (kg/m^3)	Mean Density (kg/m^3)
1	A	16.971	6.986	19.156	1.77 x 10^3	1.77 x 10^3
	B	17.068	7.023	19.064	1.78 x 10^3
	C	17.268	7.105	19.055	1.78 x 10^3
2	A	17.227	7.029	17.197	1.79 x 10^3	1.77 x 10^3
	B	18.378	7.509	17.505	1.76 x 10^3
	C	16.996	6.939	17.334	1.77 x 10^3

Mean density:  1.77 x 10³ kg/m³
Relative density: 1.77
Temperature:  20.0 ± 0.5 °C

Applicant's summary and conclusion

Conclusions:

The density of the test item has been determined to be 1.77 x 10^3 kg/m3 at 20.0 ± 0.5 °C; relative density: 1.77.

Executive summary:

Density. 1.77 x 10³kg/m³ at 20.0 ± 0.5 °C, relative density: 1.77, using a gas comparison pycnometer, designed to be compatible with Method A.3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.