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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb 22 1995 - May 6 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: OECD 105
GLP compliance:
yes
Medium:
other: n-heptane
Solubility:
2.1 g/L
Temp.:
20 °C
Medium:
n-octanol
Solubility:
20 g/L
Temp.:
20 °C
Medium:
other: 2-propanol
Solubility:
32 g/L
Temp.:
20 °C
Medium:
other: Polyethyleneglycol (PEG)
Solubility:
58 g/L
Temp.:
20 °C
Medium:
DMSO
Solubility:
210 g/L
Temp.:
20 °C
Medium:
acetone
Solubility:
> 250 g/L
Temp.:
20 °C
Medium:
acetonitrile
Solubility:
> 250 g/L
Temp.:
20 °C
Medium:
other: Dichloromethane
Solubility:
> 250 g/L
Temp.:
20 °C
Medium:
ethyl acetate
Solubility:
> 250 g/L
Temp.:
20 °C
Medium:
other: Xylene
Solubility:
> 250 g/L
Temp.:
20 °C
Test substance stable:
yes

Summary of results

The means from the results of 2 concentration measurements for each stirring time considering dilution factors are summarized in the table given below. There is no significant dependence on the stirring time

showing that the solubility equilibrium was reached after 30 mins. of stirring. Consequently, all values in each of the series were included to calculate means and standard deviations.

Summary of results

 

0.5 hrs.

hr.

2 hrs.

4 hrs.

8 hrs.

24 hrs.

(72hrs.

1-octanol)

mean

(standard

deviation)

 

[ g / L ]

[ g / L ]

[ g / L ]

[ g / L ]

[ g / L ]

[ g / L ]

 

n-Heptane

2.00

2.08

1.85

2.21

2.14

2.06

2.06

(6.03 %)

1-Octanol

19.37

19.54

19.56

20.20

19.89

23.00

20.26

(6.78 %)

2-Propanol

33.24

33.24

31.54

31.14

32.31

29.14

31.77

(4.87 %)

Polyethyleneglycol

57.11

58.68

56.90

57.66

57.10

59.22

57.78

(1 .66 %)

Dimethylsulfoxide

211

212

202

209

214

212

210

(2.02 %)

Acetone

-21)

-

-

-

-

-

> 250 g/L

Acetonitrile

-21)

-

-

-

-

-

> 250 g/L

Ethylacetate

-21)

-

-

-

-

-

> 250 g/L

Dichloromethane

-21)

-

-

-

~

-

> 250 g/L

Xylene

-21)

-

-

-

-

-

> 250 g/L

21) Solubilities above 250 g/L were not determined.

Description of key information

Solubility (at 20 °C) in organic solvents (Adapted OECD guideline 105, flask method):

 

Solvent

Solubility at 20°C

n-Heptane

2.1 g/L

1-Octanol

20 g/L

2-Propanol

32 g/L

Polyethyleneglycol (PEG)

58 g/L

Dimethylsulfoxide (DMSO)

210 g/L

Acetone

> 250 g/L

Acetonitrile

> 250 g/L

Dichloromethane

> 250 g/L

Ethylacetate

> 250 g/L

Xylene

> 250 g/L

Key value for chemical safety assessment

Additional information