Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

06 November 2017 to 16 November 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Guideline study as required by REACH regulation 1907/2006

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

27 July 1995

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

30 May 2008

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Name: dermofeel® PA-3 (dried)
- CAS No.: 14306-25-3
- EC No.: 238-242-6
- Source and lot/batch No.of test material:
NA2253
- Appearance: white solid powder
- Production date: June 2016
- Expiration date of the lot/batch:
June 2019

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
closed vessel; room temperature (16.0 - 21.6°C); protected from light and humidity
- Solubility and stability of the test substance in the solvent/vehicle:
not applicable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium:
not applicable

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
The test item was ground and dried at least overnight. Drying was done in a desiccator.
- Preliminary purification step (if any): not applicable
- Final dilution of a dissolved solid, stock liquid or gel: not applicable
- Final preparation of a solid: not applicable

FORM AS APPLIED IN THE TEST (if different from that of starting material)

same form as starting material (white solid powder)

TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable)
not applicable

OTHER SPECIFICS:
Total phosphorus content: 21.6%
Homogeneity: homogenous

Key result

Decomposition:

yes

Decomp. temp.:

>= 71.27 °C

Remarks on result:

not determinable

Remarks:

test item decomposed before boiling

Pre-test for melting range

The capillary tube containing the test item was set into the block at 19.3 °C. The block was heated until melting started. The temperature was noted at which the first signs of melting of the test item were observed. When the substance was completely melted, the temperature should be noted again. All observations of the Pre-test for melting range are presented in the following table.

 

Table     Results of the pre-test

Observations	Temperature
The test item shrivelled together	Since 80 °C
The test item expanded upwards	Since 105 °C
No test item at the bottom visible (further expanded upwards). The test item getting glossier, original is slightly matt.	Since 120 °C
The colour getting darker (yellowish)	Since 140 °C
Performance of heating, interpreted decomposition (melting under decomposition)	Up to 155 °C
The test item was solid and stayed yellowish	After cooling down

Interpretation

In Pre-test for melting range a colour and a physical state changes were observed which might be a signs for decomposition.

After consulting with the sponsor the first DSC measurement should be performed from 15 to 175 °C. Therefore the Security Pre-test for the DSC instrument was performed up to 420 °C with and without perforated aluminium lid.

For the crucible with perforated aluminium lid the test item was black and came out from the perforated position. For the crucible without perforated aluminium lid the crucible was bloated.

In both DSC measurements one endothermic event was detected.

The endothermic event was evaluated with the onset function and can be identified as melting point.

In the further process after melting an unsmooth baseline was visible and was probably supposed as a sign of decomposition. This was evaluated with the event marker function.

The observations of pre-test and the physical state change of the test item in crucible after DSC measurement confirm decomposition.

Presentation of results

For the calculation of the values of the mean and the standard deviation, only the values of melting point were taken into account.

Table8.7‑a     Calculated values

Melting point	in °C	in K
1 Determination	53.36	326.51
2 Determination	53.78	326.93
Mean	53.57	326.72
sd	0.30	0.30
Begin of decomposition	in °C	in K
1 Determination	102.74	375.89
2 Determination	71.27	344.42
Min	71.27	344.42
Max	102.74	375.89

Validity

As the deviation between the two evaluated determinations (melting point) was < 0.5 K the result can be considered valid.

Conclusions:

Beginning decomposition was observed at 71.27 °C (344.42 K) before boiling point.

Executive summary:

The boiling point of the test item was determined via DSC (differential scanning calorimetry) in a combined study according to OECD 102/103 .

In both DSC measurements one endothermic event was detected, this was evaluated with the onset function and can identified as melting point under these circumstances with:

53.57 ± 0.30 °C (326.72 ± 0.30 K)

These values are the means of two independent determinations.

In further process after melting an unsmooth baseline was visible and was probably supposed as a sign of decomposition. This was evaluated with the event marker function and

beginning of decomposition should be stated as

71.27 °C (344.42 K).

No boiling point of the test item can be determined under these circumstances as the test item decomposed before boiling.

Description of key information

Beginning of decomposition at 71.27 °C (344.42 K) before boiling (Method OECD 103; respectively to EC Guideline EU A.2; differential scanning calorimetry (DSC))

Additional information

The boiling point of the substance was evaluated according to the OECD Guideline 103 and EU Method A.2. No boiling point was determined as beginning of decompoisition was observed during the study at

71.27 °C (344.42 K).