Phenol, 4,4'-(1-methylethylidene)bis-, oligomer with (chloromethyl)oxirane and ethylenediamine, reaction products with carbon disulphide, potassium salts

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

96 hours, performed 2004

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

Marine study on invertebrates following guidance. No confirmatory analysis, but substance is soluble and stable in water.
The product tested was commercial grade and included solvents and water; these solvents are of low toxicity to aquaitc and marine organisms and are not considered to have affected the outcome of the results.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Version / remarks:

Marine species; no supporting analysis

GLP compliance:

yes

Specific details on test material used for the study:

Test material supplied to the laboratory as ca 50% commercial grade mixture in ethanediol and butanol with water.
The presence of these solvents were not considered to impact on the test result.

Analytical monitoring:

no

Vehicle:

no

Details on test solutions:

Dissolved directly in water. Substance is miscible in all proportions and is supplied as 50% solution in water.

Test organisms (species):

Cyprinodon variegatus

Test type:

semi-static

Water media type:

saltwater

Limit test:

no

Total exposure duration:

96 h

Remarks on exposure duration:

Guidelines

Test temperature:

18 - 22 C

Dissolved oxygen:

> 60%

Salinity:

Synthetic seawater with salinity ca 3.3%

Nominal and measured concentrations:

0, 10, 30, 100, 300, 1000 mg/l expressed as test material received by laboratory at 50% actives
0, 5, 15, 50, 150, 500 mg/l estimated as actives

Details on test conditions:

Semi-static with exchange at 48 hours

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 275 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

ca. 150 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Details on results:

Reported LC50 550 mg/l based on 50% actives material used for testing
The test concentration of 300 mg/l material received (ca 150 mg/l actives) resulted in no mortalities.

Conclusions:

NOEC > 100 mg/l for the actives and classification not needed on the basis of this study
LC50 estimated at ca 275 mg/l actives
Marine study on invertebrates following guidance. No confirmatory analysis, but substance is soluble and stable in water.
The product testeed was commercial grade and included solvents; these solvents are of low toxicity to aquaitc and marine organisms and are not considered to have affected the outcome of the results.

Description of key information

NOEC > 100 mg/l for the actives and classification not needed on the basis of this study

LC50 estimated at ca 275 mg/l actives

Key value for chemical safety assessment

Marine water fish

Marine water fish

Effect concentration:

275 mg/L