Bis[[2,2',2''-nitrilotris[ethanolato]](1-)-N,O]bis(propan-2-olato)titanium

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to aquatic algae and cyanobacteria

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 2

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Qualifier:

according to guideline

Guideline:

other: German Industrial Standard DIN 38412 part 9

GLP compliance:

not specified

Test organisms (species):

Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

ca. 512 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

ca. 216 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Validity criteria fulfilled:

yes

Conclusions:

The EC50 of triethanoamine was 512, 216 mg/L in neutralized and non-neutralized systems.

Reference 3

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

no guideline available

Principles of method if other than guideline:

The concentration of the algal suspension is measured turbidimetrically and expressed by the extinction of the primary light of the monochromatic radiation at 578 nm for a layer of 10 mm thickness.

GLP compliance:

not specified

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Scenedesmus quadricauda

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

7 d

Key result

Duration:

7 d

Dose descriptor:

other: toxicity threshold

Effect conc.:

ca. 1 800 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: mean extinction value

Validity criteria fulfilled:

not applicable

Conclusions:

The toxicity threshold (TT) of 2-propanol to Secenedesmus quadricauda is 1800 mg/l based on a 7 d test.

Description of key information

No studies were conducted on the target substance, Bis[[2,2',2''-nitrilotris[ethanolato]](1-)-N,O]bis(propan-2-olato)titanium. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. 

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and organic 2-propanol and 2,2',2''-Nitrilotriethanol (triethanolamine). The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply. The short-term aquatic toxicity studies of triethanolamine and 2-propanol are well-investigated are used for CSA.

Key value for chemical safety assessment

EC50 for freshwater algae:

512 mg/L