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Diss Factsheets
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EC number: 252-390-9 | CAS number: 35141-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a summary report is available with basic data. Lack of detail on test material
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Only the eyes of rabbits not staining with 5% fluorescein in 20 s contact were accepted for the study. Single instillation of 0.005, 0.02, 0.1, or 0.5 mL undiluted or 0.5 ml of 40, 15, 5, or 1% test material dilutions were made into the conjunctival sac of 5 rabbits. The eyes were read immediately unstained and after fluorescein at 24 h, with 1 of 10 grades assigned. Trace or no injury from undiluted test material = Grade 1.
- GLP compliance:
- no
Test material
- Reference substance name:
- N-(2-aminoethyl)-N'-[3-(trimethoxysilyl)propyl]ethylenediamine
- EC Number:
- 252-390-9
- EC Name:
- N-(2-aminoethyl)-N'-[3-(trimethoxysilyl)propyl]ethylenediamine
- Cas Number:
- 35141-30-1
- Molecular formula:
- C10H27N3O3Si
- IUPAC Name:
- 3,3-dimethoxy-2-oxa-7,10-diaza-3-siladodecan-12-amine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Diet: Rockland diets ad libitum
- Water: ad libitum (not further specified)
Test system
- Vehicle:
- other: Both undiluted and diluted in solvent (not further specified) was tested.
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.005, 0.02, 0.1, or 0.5 mL undiluted or 0.5 mLof dilutions
- Concentration (if solution): 40, 15, 5, or 1% - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 24 h
- Number of animals or in vitro replicates:
- 5
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
SCORING SYSTEM: 1 of 10 grades assigned. Trace or no injury from undiluted test material = Grade 1.
TOOL USED TO ASSESS SCORE: with and without fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- out of all animals tetsed
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- other: Moderate corneal injury with iritis from 0.5 mL undiluted test material per eye; mild or moderate corneal injury from 0.1 mL, with iritis, or 0.02 mL per eye.
- Irritant / corrosive response data:
- Moderate corneal injury with iritis from 0.5 mL undiluted test material per eye; mild or moderate corneal injury from 0.1 mL, with iritis, or 0.02 mL per eye.
- Other effects:
- No further effects were reported.
Applicant's summary and conclusion
- Conclusions:
- The submission substance was tested for its eye irritating properties in a non-guideline study and without GLP compliance. Single instillation of 0.005, 0.02, 0.1, or 0.5 mL undiluted or 0.5 ml of 40, 15, 5, or 1% test material dilutions were made into the conjunctival sac of 5 rabbits. Moderate corneal injury with iritis from 0.5 mL undiluted test material per eye; mild or moderate corneal injury from 0.1 mL, with iritis, or 0.02 mL per eye. Hence, the test item was concluded to be moderately irritating to the eyes.
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