N-cyclohexylcyclohexanamine 2-[1-[[[(1R)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-01-13 to 2014-05-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Principles of method if other than guideline:

No deviation from standard procedure

GLP compliance:

yes

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Temp.:

ca. 25

Vapour pressure:

ca. 0 Pa

Remarks on result:

other: Vapour pressure at 25°C

Temp.:

ca. 20

Vapour pressure:

ca. 0 Pa

Remarks on result:

other: Vapour pressure at 20°C

	20°C		25°C
	[Pa]	[mmHg]	[Pa]	[mmHg]
Test substance	3.6´10-6	2.7´10-8	1.1´10-5	8.0´10-8

Conclusions:

The vapour pressure of the test substance was 0.0000036 Pa at 20°C (293K) and 0.000011 Pa at 25°C (298K).

Executive summary:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of Montelukast Dicyclohexylamine Salt. From 120°C upwards, non linear weight losses were observed. Though weight loss was also observed from 150°C during the preliminary test of the melting and boiling temperature study, it is unknown what caused this weight loss. The equation of the plot of the log PT of the test substance as function of the reciprocal temperatures was: log PT = -8371 x 1/T + 23.11 (r = 0.96, n = 6). Since the coefficient of correlation (r) was < 0.99, two additional experiments were performed with a different temperature programme. The results given above are from the two additional experiements.

Description of key information

The key study conducted per OECD test method and under GLP  conditions reported the vapour pressure of the test substance was 0.0000036 Pa at 20°C (293K) and 0.000011 Pa at 25°C (298K).

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C

Additional information

The isothermal TGA effusion method was applied for the determination of the vapour pressure of Montelukast Dicyclohexylamine Salt. From 120°C upwards, non linear weight losses were observed. Though weight loss was also observed from 150°C during the preliminary test of the melting and boiling temperature study, it is unknown what caused this weight loss. The equation of the plot of the log PT of the test substance as function of the reciprocal temperatures was: log PT = -8371 x 1/T + 23.11 (r = 0.96, n = 6). Since the coefficient of correlation (r) was < 0.99, two additional experiments were performed with a different temperature programme. The results given above are from the two additional experiements.