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EC number: 203-937-5 | CAS number: 112-12-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- Data is from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study of Methyl nonyl ketone (112-12-9) in rabbit
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials: Menthone Racemic
- Author:
- D. L. J. Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology,Volume 13, Issue 6, 1975, Pages 869-870
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study in rabbit for CAS no: 112-12-9
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- Gestis Substance Database ,2018
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study of Methyl nonyl ketone (112-12-9)
- Author:
- MaryAdele J’o Neil
- Year:
- 2 006
- Bibliographic source:
- The Merck Index, 14th Edition,Pg 6100, 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Undecan-2-one
- EC Number:
- 203-937-5
- EC Name:
- Undecan-2-one
- Cas Number:
- 112-12-9
- Molecular formula:
- C11H22O
- IUPAC Name:
- undecan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): Methyl nonyl ketone
- Common name: 2-Undecanone
- Molecular formula: C11H22O
- Molecular weight: 170.294 g/mol
- Smiles notation: C(CCCCCC)CCC(C)=O
- InChl: 1S/C11H22O/c1-3-4-5-6-7-8-9-10-11(2)12/h3-10H2,1-2H3
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 4 animals/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed for mortality and systemic effects over a 14 day period.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at dose 5000 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The lethal concentration (LD50) value for acute dermal toxicity test was considered to be >5000 mg/kg bw,when rabbits were treated with test chemical Methyl nonyl ketone via dermal route.
- Executive summary:
Acute dermal toxicity study was performed in rabbits using test chemical Methyl nonyl ketone (CAS no.: 112 -12 -9, E.C. no.: 203 -937 -5). 4male and 4female rabbits were treated at a dose concentration of 5000mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality. No mortality was observed at dose 5000 mg/kg bw. Hence, the LD50 value was considered to be >5000mg/kg bw,when rabbits were treated with test chemical Methyl nonyl ketone via dermal route. The test chemical can be considered as "Not classified" according to the CLP.
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