Registration Dossier
Registration Dossier
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EC number: 209-506-8 | CAS number: 583-52-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- (no details on test animals and environmental conditions were given
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity and Skin Corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions
- Author:
- Vernot, E.H. et al.
- Year:
- 1 977
- Bibliographic source:
- Toxicol Appl Pharmacol. 42:417-23.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral dose toxicity was usually determined by the method of Smyth et al. (1962) in which the LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947; Weil, 1952). Occasionally enough data were obtained to use the probit method (Finney, 197 1) for calculation.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Oxalic acid
- EC Number:
- 205-634-3
- EC Name:
- Oxalic acid
- Cas Number:
- 144-62-7
- Molecular formula:
- C2H2O4
- IUPAC Name:
- oxalic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Diet: Purina Formulab Chow 5008
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 7.5 mL/kg bw
- Based on:
- test mat.
- Remarks:
- 5% (w/v) in aqueous solution
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 9.5 mL/kg bw
- Based on:
- test mat.
- Remarks:
- 5% (w/v) in aqueous solution
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 375 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 100% by calculation
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 475 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 100% by calculation
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 4 based on CLP/EU GHS criteria, according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: Acute Oral 4, H302 (Annex VI harmonized classification)
The available data on acute toxicity (oral) are in consistency with the harmonized classification according to Regulation (EC) 1272/2008, Annex VI.
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