Coriander, ext.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May - June 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected on 13 and 14 October 2014 / signed on 08 April 2015

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

ca. 178.5 °C

Atm. press.:

ca. 101 325 Pa

Remarks on result:

other: 178.5 ± 1.2 °C (corresponding to 451.6 ± 1.2 K)

Results

Observations and measured values are presented in the following table.

Table 4.3/1-Results

Determination	Boiling Point	Atmospheric Pressure
First determination	178.5 °C (451.7 K)	99282 Pa
Second determination	159.0 °C (432.2 K)	98181 Pa
Third determination	176.4 °C (449.6 K)	98181 Pa

As the third determination confirmed the result of the first determination, experiments 1 and 3 were used for evaluation andcalculation of the value of the mean.

Table 4.3/2.-Observations

Observation	First determination	Second determination	Third determination
Formations of small bubbles from bottom of reagent glass/ Boiling chain	Approx. 180 °C / 203.2°C	Approx. 165 °C / 195.3°C	Approx. 147 °C / 194.0°C
After cooling down	Test item unchanged by visual inspection

Second determination was discarded.

Corrected values following Sidney-Young: to calculate the boiling temperature at standard pressure (101325 kPa)

Table 4.3/3.-Corrected values to the standard presure 101.325kPa

	Boiling point	Pressure in Pa	Corrected Boling point
First determination	178.5 °C (451.7 K)	99282 Pa	179.3 °C (452.5 K)
Second determination	159.0 °C (432.2 K)	98181 Pa	160.2 °C (433.3 K)
Third determination	176.4 °C (449.6 K)	98181 Pa	177.6 ^C (450.8 K)
Mean			178.5 °C (451.6 K)

Mean ± standard deviation (after correction following Sydney Young) = 178.5 ± 1.2 °C (451.6 ± 1.2 K) at standard pressure (101.325 kPa).

Conclusions:

The initial boiling point of the test item has been determined to be ca 178.5 ± 1.2 °C (451.6 ± 1.2 K), corrected to standard pressure (101.325 kPa).

Executive summary:

The initial boiling point of the test item was measured under GLP according to OECD 103 / EU A2 guideline, by Siwoloboff.The test item was filled into a sample tube.

The sample tube was then set into the aluminium block at 180.0 °C (first determination), at 165.0 °C (second determination) and 147.3°C (third determination).

For the increase of the temperature, a temperature gradient of 1 °C /min was maintained. When bubbles rose constantly on the capillary, heating was turned down, and, cooling slowly. The moment at which the chain of bubbles broke was recorded (with its atmospheric pressure) as boiling point. The determination was performed in duplicate with fresh samples.

The test item was unchanged after cooling down for each determination.

Description of key information

The initial boiling temperature of the test item has been determined to be ca 178.5± 1.2°C, corrected to standard pressure (101.325 kPa).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

178.5 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study.

The initial boiling point of the test item was measured using the Siwoloboff method.The test item was filled into a sample tube.

The sample tube was then set into the aluminium block at 180.0 °C (first determination), at 165.0 °C (second determination) and 147.3°C (third determination).

For the increase of the temperature, a temperature gradient of 1 °C /min was maintained. When bubbles rose constantly on the capillary, heating was turned down, and, cooling slowly. The moment at which the chain of bubbles broke was recorded (with its atmospheric pressure) as boiling point. The determination was performed in duplicate with fresh samples.

The test item was unchanged after cooling down for each determination.