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EC number: 231-995-1 | CAS number: 7783-40-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 January 2017 – 03 February 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- None deviations from the guideline was recorded.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Materion / lot 662599-1
- Expiration date of the lot/batch: 31-Jul 2017
- Purity test date: 18- Jan-2016
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: RT, away from moisture
- Stability under test conditions: stable
- Solubility and stability of the test substance in the solvent/vehicle: low solubility
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not expected - Analytical monitoring:
- yes
- Remarks:
- ICP-OES-Method to determine Magnesium in the test item was validated.
- Details on sampling:
- Samples were WAFs. This was done by weighing the nominal load 100 mg/L (real load 100.09 mg/L), adding the corresponding amount of tap water and stirring for 23.5 hours. The resulting solution was filtrated through 0.45 µm Cellulose ester filters. Sampling intervals were 0, 24, 48, 72 and 96 hours.
- Vehicle:
- no
- Details on test solutions:
- The water-accommodated fraction (WAF) was prepared for the test a day before starting the test. It was done by weighing the nominal load 100 mg/L (real load 100.09 mg/L), adding tap water and stirring for 23.5 hours. The resulting solution was filtrated through 0.45 µm Cellulose ester filters.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Danio rerio HAMILTON-BUCHANAN
- Source: Dehner Garten Center, 67433 Neustadt
- Age at study initiation (mean and range, SD): sexually immature young fish
- Length at study initiation: length 2 +- 1 cm
-Vessels: polyethylene aquaria
ACCLIMATION
- Acclimation period: 12 days
- Acclimation conditions: same as test
- Type and amount of food during acclimation: warmwater fishfood about 1-2% of body weight per day
- Feeding frequency during acclimation: three times a day
- Health during acclimation: mortality did not surpass 5 %
FEEDING DURING TEST
The test fish were no longer fed 24 hours before the start of the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 0.83 mmol/L
- Test temperature:
- 22.0 – 22.6 °C, were measured at 0h, 24h, 48h, 72h and 96h in the control and loaded conc.
- pH:
- 7.9-8
- Dissolved oxygen:
- 9.6-7.7 O2 in mg/L, were measured at 0h, 24h, 48h, 72h and 96h in the control and loaded conc.
- Conductivity:
- 228 µS/cm
- Nominal and measured concentrations:
- blank control and nominal concenration of 100 mg/L (real load 100.09 mg/L)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria, maximal volume 10 L
- Material, size, headspace, fill volume: 10 L
- Aeration: accomplished with glass tubes
- Type of flow-through (e.g. peristaltic or proportional diluter):
- Renewal rate of test solution: none
- No. of organisms per vessel: loading of 1 fish/L, 7 fishes per vessel
- No. of vessels per concentration (replicates): 1 vessel per concentration, each containing 7 L test solution and 7 fish
- No. of vessels per control (replicates): 1 vessel, each containing 7 L test solution and 7 fish
- No. of vessels per vehicle control (replicates): 1 vessel, each containing 7 L test solution and 7 fish
TEST MEDIUM / WATER PARAMETERS (see details in section "Any other information in results incl. tables", table 4)
- Source/preparation of dilution water: Good quality drinking water was used, chlorine-free tap water
- Total organic carbon: < 0.50 mg/L
- Metals: Na, K, Ca, Mg, Al, Fe, Mn, Nh4, NO3, NO2, Sb, As, Pb, Cd, Cr, Cu, Ni, Hg, Se, B, F, were measured.
- Pesticides: < LOD µg/L
- Chlorine: 10 mg/L
- Ca/mg ratio: 32 mg/L
- Intervals of water quality measurement: : Mar. 2016, Wasserwerk Kirrweiler
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 12/12 hours, using neon tubes
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: In the non-GLP pre-test no toxicity on the test organisms (Danio) was observed using the 100 mg/L test item in medium. Therefore, a limit test with 100 mg/L will be performed only
- Test concentrations: blank control and 100 mg/L - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of loaded concentrations: No mortality was observed.
- Behavioural abnormalities: No abnormal behaviour of the surviving fish was observed - Other biological observations:
- Mortality of control: No mortality was observed.
- Abnormal responses: No abnormal behaviour of the surviving fish was observed
See section "Any other information on results incl. tables" for details on results (table 5, table 6, table 7, table 8 and table 9) - Sublethal observations / clinical signs:
Table 4. Date of analysis: Mar. 2016, Wasserwerk Kirrweiler Parameter Value Unit sodium 4.7 mg/L potassium 2.6 mg/L calcium 32 mg/L magnesium 3.6 mg/L aluminium 0.011 mg/L iron <0.005 mg/L manganese <0.005 mg/L ammonium <0.05 mg/L nitrate 5.5 mg/L nitrite <0.005 mg/L chloride 10 mg/L sulphate 11 mg/L total organic carbon (TOC) < 0.50 mg/L antimony <0.001 mg/L arsenic <0.001 mg/L lead <0.001 mg/L cadmium <0.0001 mg/L chromium <0.001 mg/L copper <0.001 mg/L nickel <0.001 mg/L mercury <0.0001 mg/L selenium <0.001 mg/L bor <0.01 mg/L cyanide <0.005 mg/L fluoride <0.1 mg/L benzene <0.1 µg/L polycyclic aromatic hydrocarbons <0.008 µg/L chlorinated organic compounds <1 µg/L pesticides and biocides < LOD µg/L pH 8.16 conductivity at 25 °C 228 µS/cm hardness 0.83 mmol/L LOD = limit of detection Table 5. Mortality Nominal Conc. in mg/L Total number of fish used Number of dead fish 24 h 48 h 72 h 96 h Blank control 7 0 0 0 0 100 7 0 0 0
0
Table 6. pH and O2 values Nominal Conc. in mg/L pH at t O2 in mg/L at t mg/L 0 h 24 h 48 h 72 h 96 h 0 h 24 h 48 h 72 h 96 h Blank control 7.9 7.9 7.9 7.9 8 9.6 8.3 8.6 7.7 8.1 100 8 8 8 7.9 8 8.1 8 8.1 7.3 7.7 Table 7. Temperature 0 h 24 h 48 h 72 h 96 h Temperature in °C 22.6 22.3 22 22.2 22.5 Table 9. Biological Results Parameter Value NOEC ≥ 100 mg/L LOEC > 100 mg/L 96h LC50 > 100 mg/L - Validity criteria fulfilled:
- yes
- Remarks:
- No mortality occurred in the blank control. The concentration of dissolved oxygen was at least 7.3 mg/L or 84.5 % throughout the test The highest variation pf pH was 0.1 units.
- Conclusions:
- In this study, the 96-h acute toxicity (mortality) to 7 fish (Danio rerio) was tested by using a static test design. None of the animals were immobilised in the treatment and in the blank control.
The following results for the test item were determined:
96h-NOEC ≥ 100 mg/L;
96h-LOEC > 100 mg/L;
96h-EC50 > 100 mg/L - Executive summary:
The 96-h acute toxicity to fish (Danio rerio) was determined by using a static test design. The test followed EU-Method C.1. resp. OECD Guideline 203 and it was performed as a limit test using the nominal concentration of 100 mg/L. None of the animals were immobilised in the treatment and in the blank control.
At the start and at the end of the test, the content of Magnesium in the test solutions was determined using ICP-OES. Only in the test solution at the end of the test a very low concentration of Magnesium was detectable. All other measured values are below the LOD. Therefore, the determination of the biological results was based on the nominal concentration.
Reference
Description of key information
The acute test (OECD 203) of Zebrafish (Danio rerio) to Magnesium fluoride was determined using static test system and nominal concentrations at controlled conditions. The study was conducted according to OECD 203 and followed OECD Principles of Good Laboratory Practice (GLP). No unusual observations or deviations from standard test protocol were noted. As a result, 96-h LC50 was calculated as >100 mg/L.
Based on the available data, the 96-h LC50-value was selected as a key value.
The data obtained from testing on freshwater species has been used as basis for assessment of effects in marine environment as well as for extrapolation of the measured effects to other compartments within the aquatic ecosystem (e.g. sediment) and soil.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 100 mg/L
Additional information
The short-term toxicity to fish results obtained from the supporting read-across substance (sodium fluoride) has been provided.
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