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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable with restrictions because although it is a pre-guideline study, it is similar to current guidelines and is sufficient to assess the acute toxicity of dodecane-1-thiol.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
Only one dose level was used and observations were made after only 7 days. Necroscopy and gross pathology results were not provided.
Principles of method if other than guideline:
In pre-guideline studiesanother study, WBS/W rats (6 males) were treated dermally with 2000 mg/kg body weight of dodecane-1-thiol. The occluding sleeve was removed 24 hours following exposure and the animals were observed for 7 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Dodecane-1-thiol (CAS # 112-55-0)
IUPAC Name:
Dodecane-1-thiol (CAS # 112-55-0)
Details on test material:
- Name of test material (as cited in study report): n-dodecyl mercaptan (dodecane-1-thiol)
- Other: density = 0.838 g/mL

Test animals

Species:
rat
Strain:
other: WBS/W
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
- Area of exposure: skin under the trunk
- Type of wrap if used: occluding sleeve


REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 hours


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
Duration of exposure:
24 hours
Doses:
2000 mg/kg
No. of animals per sex per dose:
6

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw
Remarks on result:
other: Based on lack of moratlity and adverse effects
Mortality:
No mortality was observed.
Clinical signs:
other: No clinical signs were observed.

Any other information on results incl. tables

All animals remained asymptomatic and gained body weight during the observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 is >2000 mg/kg bw.
Executive summary:

In an acute dermal toxicity study, six male albino rats were dermally exposed to dodecane-1-thiol by an undescribed method at 2000 mg/ kg dose. Animals then were observed for seven days.

 

All animals remained asymptomatic and gained body weight during the observation period. The acute dermal LD50 was therefore determined to be >2000 mg/kg bw.

This study received a Klimisch score of 2 and is classified as reliable with restrictions because although it is a pre-guideline study, it is similar to current guidelines and is sufficient to assess the acute toxicity of dodecane-1thiol.