Registration Dossier
Registration Dossier
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EC number: 423-740-1 | CAS number: 10461-98-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Cyclohexenecarbonitrile expected to have Low bio-accumulation potential based on study results.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
In a in vivo metabolism study,Sprague-Dawley rats cell line were treated withCyclohexenecarbonitriledissolved in a 20 μl pentane was applied to a moist piece of filter paper (1 × 3 cm) adhering inside the neck of the flask just prior to capping the flask.. Cyclohexenecarbonitrileappears toshows loweer oder of toxicity to hepatecytes by low GPT release with half-maximal release of GPT within 2 h as 12 mM as compared to bromobenzene which show 2.4 mM. Which is much lower than Cyclohexenecarbonitrile. Hance, it is clear that neither the presence of a simple Michael acceptor function (Cyclohexenecarbonitrile) nor the presence of a simple epoxide moiety is sufficient to render the molecule a potent toxin.Therefore,Cyclohexenecarbonitrile considered to haveLow bio-accumulation potential based on study results.
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