4-methoxybenzyl alcohol

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015-12-17 to 2016-01-05

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

no

Remarks:

The study was conducted under GLP equivalent conditions. The study was conducted under supervision of a quality assurance unit which had ensured e.g instrumentation validation, reagent/materials certification, analyst certification and providing SOPs.

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

257 °C

Atm. press.:

1 013.25 hPa

Decomposition:

no

Results of the DSC-measurements

No.	Sample weight / mg	Onset of Effect / °C	Range of effect / °C	Weight loss / mg	Atmospheric pressure / hPa
1	10.84	19.42 256.83	0 – 30 (endo) 190 – 280 (endo)	10.78	1013.7
2	16.00	21.48 255.76	10 – 30 (endo) 180 – 280 (endo)	15.97	979.3

 

The test item showed a second endothermic signal in the temperature range of approx. 180 – 280 °C that can be assigned to the boiling of the test item. For the correction of the boiling temperature to standard pressure the test item was assigned to chemical group 5 (e.g. Benzyl alcohol). According to Equation, table and figures of H.N. Hass and R.F. Newton (see „CRC Handbook of Chemistry and Physics, 74th ed. 1993-1994“) a correction value φ= 5.8 was used for the temperature of 250 – 260 °C. The lowest measured onset temperature is corrected to the standard pressure to be 256.81 °C and the highest onset temperature to be 257.11 °C. As the corrected onset temperatures in both tests deviate by less than 0.5 K from their mean value of 256.96 °C, a boiling point of 257 °C was determined. No further thermal effects were observed up to the maximum test temperature of 500 °C.

Conclusions:

The boiling point was estimated to be 257 °C at 1013.25 hPa.

Executive summary:

A study was conducted according to OECD test guideline 103, Regulation (EC) No 440/2008 method A.2 and EPA OCSPP test guideline 830.7220 to determine the boiling point of the test item using differential scanning calorimetry. The test item was weighed out into an aluminium crucible under an inert atmosphere (nitrogen). Two tests with about 11 – 16mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. The substance is a liquid at ambient conditions. Therefore the crucibles were cooled down from ambient temperature to -100 °C with a constant cooling rate of 0.25 K/min under an inert atmosphere. After a waiting period of 30 min at -100 °C, the temperature was increased up to 500 °C at a constant heating rate of 10 K/min. Between approx. 180 – 280 °C an endothermic effect (boiling) was detected. The correction of the boiling temperature to standard pressure was performed according to H.N. Hass and R.F. Newton. A boiling point of the test item of 257 °C corrected to normal atmospheric pressure was determined. No further thermal effects were observed up to the maximum test temperature of 500 °C. No observations were made which cause doubt on the validity of the outcome of the study.

 

Description of key information

The boiling point was determined to be 257 °C at 1013.25 hPa.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

257 °C

Additional information

A study was conducted according to OECD test guideline 103 to determine the boiling point of the test item using differential scanning calorimetry. A boiling point of the test item of 257 °C corrected to normal atmospheric pressure was determined. No further thermal effects were observed up to the maximum test temperature of 500 °C.