Registration Dossier
Registration Dossier
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EC number: 290-058-5 | CAS number: 90063-97-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha arvensis, Labiatae.
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test according to unspecified guideline. Very concise reporting: Species, strain, source and sex of animals, environmental conditions, and time of dosing not reported. However, report is acceptable as basic data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data on guideline available
- Deviations:
- not applicable
- Principles of method if other than guideline:
- standard acute method, no details available.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- cornmint oil
- IUPAC Name:
- cornmint oil
- Details on test material:
- - Name of test material (as cited in study report): Cornmint oil
- Lot/batch No.: confidential
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 other: g/kg bw
- Based on:
- test mat.
- Mortality:
- 0/10
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
Distribution of Mortality
| Observation Day | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| Mortality | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Based on CLP criteria
- Conclusions:
- The acute dermal toxicity (LD50) of Cornmint oil towards rabbits is > 5 g/kg bw under the conditions of this test. Based on these results the substance Cornmint oil does not need to be classified as acute toxic based on the criteria outlined in Annex I of 1272/2008/EC.
- Executive summary:
The acute dermal toxicity (LD50) of Cornmint oil towards rabbits was investigated according to a standard acute method (unspecified guideline). Rats were exposed to a single oral dose of 5 g/kg bw and were observed for 14 days. Per dose 10 rats were used. The acute toxicity (LD50) was found to be > 5 g/kg bw under the conditions of this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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