Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-818-8 | CAS number: 7757-79-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Title:
- Study of Mutagenic Effects of Potassium Nitrate by the Dominant Lethal Test in Rats.
- Author:
- Anonymous
- Year:
- 1 979
- Bibliographic source:
- Government Reports Announcements and Index. Issue 26.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- Potassium nitrate
- EC Number:
- 231-818-8
- EC Name:
- Potassium nitrate
- Cas Number:
- 7757-79-1
- Molecular formula:
- HNO3.K
- IUPAC Name:
- potassium nitrate
- Test material form:
- solid: crystalline
- Details on test material:
- Name of test material: potassium nitrate (KNO3)
Physical appearance: colourless crystalline solid or a white crystalline or granular powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 10-weeks
- Frequency of treatment:
- not stated
- Post exposure period:
- not stated
Doses / concentrations
- Remarks:
- Doses / Concentrations:
not stated
Basis:
- No. of animals per sex per dose:
- not stated
Results and discussion
Any other information on results incl. tables
Body weight gains did not show a clear dose-response effect. The weight gains ranged from 3 to 13% above control values. The dominant lethal test produced no consistent responses to suggest that potassium nitrate is mutagenic to rats.
Applicant's summary and conclusion
- Conclusions:
- Potassium nitrate tested negative in a dormant lethal assay
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
