Registration Dossier
Registration Dossier
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EC number: 205-500-4 | CAS number: 141-78-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (32 day) <9.65mg/l (growth), >75.6mg/l (hatching, survival)
NOEC (32 day) =6.9mg/l (QSAR)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6.9 mg/L
Additional information
The effects of chronic ethyl acetate exposure to Pimephales promelas (Fathead minnow) have been studied. Ethyl acetate was studied in a fish early life stage test where hatching of embryos followed by 32 -day early life stage growth of fry was assessed. The most sensitive response was growth, which was reduced(P< 0.05) at the lowest concentration tested (9.65 mg/L). However, the relationship between growth and toxicant concentration in the test was not clearly dose-related, with the greatest reduction in growth (47%) occurring at the two lowest exposure concentrations. The results do not allow a clear NOEC to be established, but it is clear that ethyl acetate is not a potent chronic toxicant; at 75mg/l, no mortality or adverse impact on hatching was seen, no mortality is evidence, and growth retardation was only reduced by 13% by length compared to controls. Based on the result however, it is reasonable to concur with the authors and conclude that the study shows a NOEC<9.65mg/l. This can be considered a conservative approach. This study is supported by a reliable QSAR which estimates that the NOEC would be 6.9mg/l for a study of the same duration, which is very consistent with the experimental data. As a conservative approach the NOEC value from the QSAR, the lower of the two values, is used as the NOEC for this end point.
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