Registration Dossier
Registration Dossier
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EC number: 202-429-0 | CAS number: 95-53-4
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: effects on fertility on parent animals
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not translated, and only short abstract available
Data source
Reference
- Title:
- No information
- Author:
- Malysheva MV, Saitzeva EP, Ivanov YuV (1983) Effects after dermal application with o-toluidine in rats. Gig Tr Prof Zabol 9: 47-49
Materials and methods
- Principles of method if other than guideline:
- Method: other: see TC
- GLP compliance:
- not specified
Test material
- Reference substance name:
- o-toluidine
- EC Number:
- 202-429-0
- EC Name:
- o-toluidine
- Cas Number:
- 95-53-4
- Molecular formula:
- C7H9N
- IUPAC Name:
- 2-methylaniline
- Details on test material:
- IUCLID4 Test substance: other TS: o-toluidine, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- dermal
- Duration of treatment / exposure:
- Exposure period: 4 month
- Frequency of treatment:
- 4 h/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
8, 80 mg/kg bw
Basis:
- Control animals:
- yes
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Effects on treated animals (P):
---increased cell numbers of the spermatogenetic tissues
---no differences on spermatogenesis during the recovery period
---increased number of corpus luteum in ovaries
---no differences on fertility and number of implants observed
for effects on progeny (F1): see chapter 5.8.2
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
