Registration Dossier
Registration Dossier
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EC number: 232-160-4 | CAS number: 7789-38-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.
- Author:
- Kurokawa Y; Maekawa A; Takahashi M; et al.
- Year:
- 1 990
- Bibliographic source:
- Environ Health Perspect 87:309-335, 1990. Cited in WHO 2005.
- Reference Type:
- other: secondary literature
- Title:
- Sodium bromate
- Author:
- HSDB
- Year:
- 2 019
- Bibliographic source:
- http://toxnet.nlm.nih.gov/
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium bromate
- EC Number:
- 232-160-4
- EC Name:
- Sodium bromate
- Cas Number:
- 7789-38-0
- Molecular formula:
- BrHO3.Na
- IUPAC Name:
- sodium bromate
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 97
- Species / strain / cell type:
- S. typhimurium TA 98
- Species / strain / cell type:
- S. typhimurium TA 100
- Species / strain / cell type:
- S. typhimurium TA 102
- Metabolic activation:
- not specified
Results and discussion
- Additional information on results:
- The mutagenic effects of sodium bromate (NaBrO3) and silver bromate (AgBrO3) were evaluated by Kurokawa et al (1990) in microbial tests with Salmonella typhimurium strains TA 97, 98, 100 and 102 to determine the general mutagenic potential of bromate compounds (BrO3). The authors stated that NaBrO3 and AgBrO3 were negative in all strains tested at maximum concentrations of 5 mg/plate and 25 µg/plate, respectively, without providing further details on the results or the method used.
- Remarks on result:
- other: unpublished data
Applicant's summary and conclusion
- Conclusions:
- Under the information reported by Kurokawa et al. (1990), sodium bromate is negative in a microbial tests conducted with Salmonella typhimurium strains TA 97, 98, 100 and 102.
- Executive summary:
The mutagenic effects of sodium bromate (NaBrO3) and silver bromate (AgBrO3) were evaluated by Kurokawa et al. (1990) in microbial tests conducted with Salmonella typhimurium strains TA 97, 98, 100 and 102 to determine the general mutagenic potential of bromate compounds (BrO3). The authors stated, that NaBrO3 and AgBrO3 were negative in all strains tested at maximum concentrations of 5 mg/plate and 25 µg/plate, respectively, without providing further details on the results.
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