Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-581-0 | CAS number: 108-42-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: study report
- Title:
- Skin Irritation Test
- Author:
- CERI
- Year:
- 2 001
- Bibliographic source:
- CERI Hazard Data 2000-35 (2001)
Materials and methods
- Principles of method if other than guideline:
- Performed in accordance with OECD Test Guideline
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-chloroaniline
- Molecular formula:C6H6ClN
- Molecular weight:127.57
- Substance type:Organic
- Physical state:Liquid
Constituent 1
Test animals
- Species:
- other: no data
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 and 48 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 48 hours
- Reversibility:
- fully reversible
- Remarks:
- by 72 hours
- Remarks on result:
- other: The substance is thus considered "mildly irritating".
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 48 hours
- Reversibility:
- fully reversible
- Remarks:
- by 72 hours
- Remarks on result:
- other: The substance is thus considered "mildly irritating."
Applicant's summary and conclusion
- Interpretation of results:
- other: mild irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Skin irritation tests performed in accordance with OECD Test Guideline: "Mild erythema and edema were induced at 24 and 48 hours, with recovery observed by 72 hours." The substance 3-chloroaniline is thus considered "mildly irritating."
- Executive summary:
Skin irritation tests performed in accordance with OECD Test Guideline: "Mild erythema and edema were induced at 24 and 48 hours, with recovery observed by 72 hours." The substance 3-chloroaniline is thus considered "mildly irritating."
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
