Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Acute toxicity : inhalation data for 108-42-9
- Author:
- Izmerov, N.F., et al.
- Year:
- 1 982
- Bibliographic source:
- "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 , 34,1982
- Reference Type:
- review article or handbook
- Title:
- DPIM : CEH675
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):-Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al., Moscow.: ,USSR,Centre of International Projects, GKNT, 1982, 34.
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number : 2046
- Author:
- Lewis, R.J.
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996.,p.728
Materials and methods
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-chloroaniline
- Molecular formula:C6H6ClN
- Molecular weight:127.57
- Substance type:Organic
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 550 other: mg/m3
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: LC50=550 mg/m3,when converted into mg/L it is equivalent to 0.55 mg/L.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal concentration (LC50) of 3 -Chloroaniline in mouse by the inhalative route was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.The mouse were given the test substance by the inhalative route at a dose concentration of 550 mg/m3 of 3-chloroaniline.The lethal concentration (LC50) of 3 -Chloroaniline in mouse was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.
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