Registration Dossier
Registration Dossier
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EC number: 266-097-9 | CAS number: 66063-15-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-chloro-N-cyclopentylbenzylamine
- EC Number:
- 266-097-9
- EC Name:
- 4-chloro-N-cyclopentylbenzylamine
- Cas Number:
- 66063-15-8
- Molecular formula:
- C12H16ClN
- IUPAC Name:
- N-[(4-chlorophenyl)methyl]cyclopentanamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- male: 100 / 300 / 400 / 500 / 750 μl/kg bw
female: 100 / 350 / 400 / 500 / 600 / 750 μl/kg bw - No. of animals per sex per dose:
- 10 animals
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 0.454 mL/kg bw
- 95% CL:
- 0.4 - 0.515
- Remarks on result:
- other: s = 1.2
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.391 mL/kg bw
- 95% CL:
- 0.334 - 0.457
- Remarks on result:
- other: s = 1.4
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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