Registration Dossier
Registration Dossier
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EC number: 266-097-9 | CAS number: 66063-15-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 4-chloro-N-cyclopentylbenzylamine
- EC Number:
- 266-097-9
- EC Name:
- 4-chloro-N-cyclopentylbenzylamine
- Cas Number:
- 66063-15-8
- Molecular formula:
- C12H16ClN
- IUPAC Name:
- N-[(4-chlorophenyl)methyl]cyclopentanamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- male: 200 / 2000 mg/kg bw
female: 200 mg/kg bw - No. of animals per sex per dose:
- male: 3 animals
female: 3 animals - Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Remarks on result:
- other: no CL given
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 300 - <= 2 000 mg/kg bw
- Remarks on result:
- other: no CL given
Any other information on results incl. tables
A dose of 200 mg/kg body weight was tolerated by male and female rats without clinical signs, without effects on body weight and without mortality.
A dose of 2000 mg/kg body weight caused in males decreased motility and reactivity, tonical cramps, rolling over, labored breathing and red salivation. The signs observed occurred within 40 - 60 minutes and lasted up to the death of the animals.
In animals that died during the observation period the following gross pathological changes were detected: liver dark-red, spleen pale and lungs with many brownish-red areas. The gross pathology investigations performed at the end of the follow-up period did not afford any findings indicative of a specific test compound effect.
Applicant's summary and conclusion
- Conclusions:
- The oral LD50 for rats was 300 - 500 mg/kg body weight.
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