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EC number: 432-080-1 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 November 1999 to 19 November 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Principles of method if other than guideline:
- The existing program ClogP 3.4, (Pomona College Medicinal Chemistry Project, Claremont, California) does not provide the possibility to calculate octanol/water partition coefficients of salts and mixtures. Therefore the partition coefficient was not calculated. Estimation from the Saturation Concentrations was instead performed.
- GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -5
- Temp.:
- 20 °C
- pH:
- 5.5
- Details on results:
- The n-octanol/water partition coefficient of the test substance estimated from its solubility in water and in n-octanol, is estimated to be log Kow = -5.0
- Conclusions:
- The n-octanol/water partition coefficient of the test substance estimated from its solubility in water and in n-octanol, is estimated to be log Kow = -5.0
- Executive summary:
The partition coefficient n-octanol/water of the test substance Reactive Orange DYPR 1410 (batch DYPR 1410 from August 17, 1998) has been determined in accordance with the guideline 92/63/EEC appendix A.8 and in compliance with GLP, from its solubility in water and in n-octanol.
It was found to be log Kow = -5.0
Reference
Experiment |
Stirring time (h) |
concentration (mg/l) |
Peak areas |
n-octanol solubility (mg/l) |
A B |
4 |
|
50.093 45.068 |
3.40 3.06 |
StandardG1 |
|
2.5388 |
37.441 |
|
A B |
4 |
|
50.093 45.068 |
3.34 3.01 |
StandardH1 |
|
2.5110 |
37.607 |
|
Description of key information
The partition coefficient n-octanol/water of the test substance was found to be log Kow=-5.0.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -5
- at the temperature of:
- 20 °C
Additional information
The partition coefficient n-octanol/water of the test substance Reaktiv-Orange DYPR 1410 has been determined in accordance with the guideline 92/63/EEC appendix A.8 and in compliance with GLP, from its solubility in water and in n-octanol.
It was found to be log Kow = -5.0
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