Registration Dossier
Registration Dossier
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EC number: 201-810-9 | CAS number: 88-21-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicokinetics study
- Author:
- Anonymous
- Year:
- 1 993
- Bibliographic source:
- Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie 252: 27 (1993)
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-Aminobenzene sulfonic acid
- IUPAC Name:
- 4-Aminobenzene sulfonic acid
- Reference substance name:
- Sulphanilic acid
- EC Number:
- 204-482-5
- EC Name:
- Sulphanilic acid
- Cas Number:
- 121-57-3
- Molecular formula:
- C6H7NO3S
- IUPAC Name:
- 4-aminobenzenesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report):4-Aminobenzene sulfonic acid
- Molecular formula (if other than submission substance):C6H7NO3S
- Molecular weight (if other than submission substance):173.19 g/mol
- Substance type:Organic
- Physical state:solid
- Impurities (identity and concentrations):NA
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intratracheal
- Vehicle:
- not specified
- Details on exposure:
- An intratracheally-instilled solution of 4- aminobenzene sulfonic acid was administered to the rat
- Duration and frequency of treatment / exposure:
- 24 hrs
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not specified
- No. of animals per sex per dose / concentration:
- Not specified
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Absorption through the lungs appears to be possible; absorption of an intratracheally-instilled solution of 4- aminobenzene sulfonic acid has been detected in the rat. 4-Aminobenzene sulfonic acid can also be absorbed from the gastrointestinal tract.
- Type:
- distribution
- Results:
- Accumulation does not take place in mammals.
- Type:
- metabolism
- Results:
- N-acetyl metabolite
- Type:
- excretion
- Results:
- 4-Aminobenzene sulfonic acid is excreted either unchanged or as the N-acetyl metabolite, in the urine and the feces in rats.Excretion after oral administration mainly occurs within 24 hr.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- N-acetyl metabolite
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
4-Aminobenzene sulfonic acid can be absorbed from the gastrointestinal tract. Absorption through the lungs appears to be possible; absorption of an intratracheally-instilled solution of 4- aminobenzene sulfonic acid has been detected in the rat. Accumulation does not take place in mammals; excretion after oral administration mainly occurs within 24 hr. 4-Aminobenzene sulfonic acid is excreted either unchanged or as the N-acetyl metabolite, in the urine and the feces in rats - Executive summary:
4-Aminobenzene sulfonic acid can be absorbed from the gastrointestinal tract. Absorption through the lungs appears to be possible; absorption of an intratracheally-instilled solution of 4- aminobenzene sulfonic acid has been detected in the rat. Accumulation does not take place in mammals; excretion after oral administration mainly occurs within 24 hr. 4-Aminobenzene sulfonic acid is excreted either unchanged or as the N-acetyl metabolite, in the urine and the feces in rats.
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