Registration Dossier
Registration Dossier
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EC number: 616-248-3 | CAS number: 75627-31-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No data is available on the toxicokinetics, metabolism and distribution of nonylphenol ethoxylate, sarcosine derivative (CAS no 75627-31-5). Based on the toxicological profile of the substance this information is not considered as a requirement. The information in this chapter has therefore been derived based on the physicochemical properties of the substance, information from QSAR models, i.e. QSAR Toolbox (v.3.1) and EpiSuite (v. 4.1) and information on bioaccumulation potential from the chapter on environmental fate and pathways.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
No data is available on the toxicokinetics, metabolism and distribution of nonylphenol ethoxylate, sarcosine derivative (CAS no 75627-31-5). Based on the toxicological profile of the substance this information is not considered as a requirement. The information in this chapter has therefore been derived based on the physicochemical properties of the substance, information from QSAR models, i.e. QSAR Toolbox (v.3.1) and EpiSuite (v. 4.1) and information on bioaccumulation potential from the chapter on environmental fate and pathways.
Nonylphenol ethoxylate, sarcosine derivative (CAS no 75627-31-5)has a molecular weight of 431.5 g/Mol, a log Kow of 3.9 and pKa value of 1.44 for the carbon and 9.39 for the nitrogen. It is a slightly water soluble solution with a vapour pressure of 0.87 Pa at 20°C.
The potential absorption via oral route is considered to be complete, although this is not a likely route of exposure. Based on the results from the EpiSuite v4.1 estimation of the absorption of the substance via dermal route is considered to be low. As a worst case, absorption via the inhalational route is also considered to be complete, although exposure to the substance via inhalation is unlikely based on the handling of the substance at dedicated facilities. The substance is not considered to have a potential for bioaccumulation, based on the Log Kow of 3.9, which is below the criterion of log Kow < 4.5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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