(2S)-3-Methyl-2-[N-({2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl}methyl)pentanamido]alkanoic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because a long-term aquatic toxicity study on fish is available

Description of key information

The results for Long term study to fish:

VAA489 VAL did not induce any significant, visible effects on the development of fathead minnow embryos or significantly affect time of hatching or the hatching success at the limit concentration of 10 mg/l. Further, VAA489 VAL did not affect survival, growth or development of the larvae at the limit concentration of 10 mg/l. Post-hatch survival in the controls and the VAA489 VAL treated replicates was > 80%.

In conclusion: the NOEC of VAA489 VAL for the early life stages of fish was 10 mg/l, the regulatory limit concentration. The overall LOEC is > 10 mg/l.