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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
100 µl test substance was applied into the conjuctival sac of 2 rabbits. Eyes were examinated after application of test substance up to 7 days
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
p-(trifluoromethoxy)phenyl isocyanate
EC Number:
252-328-0
EC Name:
p-(trifluoromethoxy)phenyl isocyanate
Cas Number:
35037-73-1
Molecular formula:
C8H4F3NO2
IUPAC Name:
1-isocyanato-4-(trifluoromethoxy)benzene

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2 animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
2.2
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 6, 7 days
Score:
2.2
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
1
Max. score:
3
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 6, 7 days
Score:
1
Max. score:
3
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 6, 7 days
Score:
1.9
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
1.9
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0.8
Max. score:
2
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 6, 7 days
Score:
0.8
Max. score:
2
Reversibility:
not fully reversible within: 7 days

Any other information on results incl. tables

4-trifluoromethoxyphenyl isocyanate is irriating

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Remarks:
Based on EU GHS criteria
Conclusions:
The conjunctiva was reddened and moderately swollen; the iris was slight to moderately swollen. The cornea was diffuse opaque. 4-trifluoromethoxyphenyl isocyanate is irriating to the eyes.
Executive summary:

100 µl test substance was applied into the conjuctival sac of 2 rabbits. Eyes were examinated after application of test substance up to 7 days. During the whole post-observation period the following symptoms were observed: The conjunctiva was reddened and moderately swollen; the iris was slight to moderately swollen. The cornea was diffuse opaque. 4-trifluoromethoxyphenyl isocyanate is irriating to the eyes.