Registration Dossier
Registration Dossier
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EC number: 201-924-9 | CAS number: 89-62-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for "Effect LOEL" read across evaluation for 99-59-2
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
Test material
- Reference substance name:
- 5-nitro-o-anisidine
- EC Number:
- 202-770-5
- EC Name:
- 5-nitro-o-anisidine
- Cas Number:
- 99-59-2
- IUPAC Name:
- 2-methoxy-5-nitroaniline
- Details on test material:
- -Name of the test material: 5-nitro-o-anisidine
-Molecular formula: C7H8N2O3
-Substance type: Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino, not further specified;Wistar;Crl:CD(SD)BR;F344/N;F344;Sprague-Dawley;Crl:(Wi)BR;Charles River;no data;CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- other: "Effect LOEL"
- Effect level:
- 205.871
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Effect: Body weight decreased
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: "effect LOEL"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.872
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 2.17
Applicant's summary and conclusion
- Conclusions:
- The repeated dose toxicity LOEL (Lowest observed effect level) of 5-nitro-o-anisidine in rat was observed at a dose concentration of 205.8714 mg/kg bw/day by the inhalative route.This indicates that 5-nitro-o-anisidine shall not exhibit toxic effect to rat by the inhalative route below the above mentioned dose.
- Executive summary:
The repeated dose toxicity LOEL (Lowest observed effect level) of 5-nitro-o-anisidine in rat was observed at a dose concentration of 205.8714 mg/kg bw/day by the inhalative route.This indicates that 5-nitro-o-anisidine shall not exhibit toxic effect to rat by the inhalative route below the above mentioned dose.
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