Registration Dossier
Registration Dossier
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EC number: 215-183-4 | CAS number: 1310-65-2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1999
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- other:
- Title:
- ECHA disseminated Dossier of Lithium hydroxide (CAS 1310-65-2)
- Year:
- 2 022
- Bibliographic source:
- ECHA disseminated Dossier of Lithium hydroxide (CAS 1310-65-2), query date 2022-03-09
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lithium hydroxide
- EC Number:
- 215-183-4
- EC Name:
- Lithium hydroxide
- Cas Number:
- 1310-65-2
- Molecular formula:
- HLiO
- IUPAC Name:
- lithium hydroxide
Constituent 1
Test animals
- Species:
- other: Mammal; species unspecified
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 6 months
Doses / concentrations
- Dose / conc.:
- 0.5 mg/kg bw/day (nominal)
Results and discussion
Results of examinations
- Details on results:
- Reduction of body weight, reduction of haemoglobin, increase of γ-Haemoglobin, reduction of catalase activity in the liver, changes in the liver function
Effect levels
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 0.05 mg/kg bw/day (nominal)
- Basis for effect level:
- other: chronic toxicity noted represents a sum of local and (primary and secondary) systemic effects
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
