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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reason / purpose for cross-reference:
exposure-related information
Reason / purpose for cross-reference:
read-across source
Duration:
7 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
7.37 mg/L
Duration:
7 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
7.45 mg/L
Duration:
7 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
8.17 mg/L
Transformation products:
yes
No.:
#1
No.:
#2
Details on hydrolysis and appearance of transformation product(s):
- Formation and decline of each transformation product during test: mono-, di-, and triester were detected; the tri-esters were rapidly degraded to di-esters, which sequentially degrade to the mono-esters
- Pathways for transformation: ester cleavage
pH:
4
Temp.:
50 °C
Hydrolysis rate constant:
0.01 h-1
DT50:
27.3 d
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
50 °C
Hydrolysis rate constant:
0.01 h-1
DT50:
72.3 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
0.01 h-1
DT50:
47.8 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
25 °C
Hydrolysis rate constant:
0.69 a-1
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
25 °C
Hydrolysis rate constant:
0.01 h-1
DT50:
17 d
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0.01 h-1
DT50:
11.3 d
Type:
(pseudo-)first order (= half-life)

Description of key information

Half-life: 
> 1 year at a pH of 4 and 25 °C
17 days at a pH of 7 and 25 °C
11.3 days at a pH of 9 and 25 °C
(OECD TG 111 / EU-method C.7, preliminary test; RL1; GLP; read-across: partially unsaturated TEA-Esterquat)

Key value for chemical safety assessment

Additional information

No experimental data on the hydrolysis of the target substance Esterification products of triglycerides C18 unsaturated with triethanolamine, dimethyl sulfate quaternized are available. However, a hydrolysis study is available for the closely related source substance partially unsaturated TEA-Esterquat. A justification for read-across is attached to Iuclid section 13.

 

The hydrolysis of partially unsaturated TEA-EQ as a function of pH was investigated in a study conducted according to OECD Guideline 111 and EU-method C.7. (Preliminary test; main test not conducted due to the pronounced biodegradability of the test substance).

The following results were obtained:

Hydrolysis of partially unsaturated TEA-EQ at 50°C

 

pH

 

Temperature (°C)

 

Rate constant

 

t1/2

 

4

50

0.00106 1/h

27.3 d

7

50

0.00958 1/h

72.3 h

9

50

0.01449 1/h

47.8 h

 

Hydrolysis of partially unsaturated TEA-EQ at 25°C

 

pH

 

Temperature (°C)

 

Rate constant

 

t1/2

 

4

25*

0.693 1/a

>1 a*

7

25

0.00169 1/h

17.0 d

9

25

0.00256 1/h

11.3 d

* default assumption acc. to guideline

 

At pH 4 and 50°C, the degradation of the main component of partially unsaturated TEA-EQ was less than 10% over a period of 120 h. The corresponding half-life at 25°C is therefore assumed to be above one year (default assumption acc. to guidelines). In contrast, at pH 7 and 9 and 50°C, more than 10% of the test item were hydrolysed within 120 h. Based on the results half-lives of 17 (pH 7) and 11.3 d (pH 9) were deduced from the reaction rate constants at 25°C. Di- and mono-ester were detected as degradation products