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Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 02 2020 to November 06 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

Not specified.

Key result

Water solubility:

64.9 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

467 mg/L

Incubation duration:

24 h

Temp.:

20 °C

pH:

6

Key result

Water solubility:

65.4 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

467 mg/L

Incubation duration:

24 h

Temp.:

20 °C

pH:

6

Key result

Water solubility:

63.3 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

467 mg/L

Incubation duration:

24 h

Temp.:

20 °C

pH:

6

Test results

Sample	pH	Concentration of test item in test solution (g/L)
		Measured value	Average
Sample-a	6.0	64.9	64.6
Sample-b	6.0	65.4
Sample-c	6.0	63.3

 

Conclusions:

The water solubility of the test item was determined to be >50 g/L at 20°C.

Executive summary:

The objective of this study was to obtain the water solubility of Dye-2019.The study was carried out in accordance with OECD test guideline No.105 in compliance with GLP. The water solubility of test item was measured by the flask method because the test item was a multi-component substance. In a preliminary test, the test item was dissolved in water at any proportion but the upper limit of water solubility was set to 50 g/L with consideration for the pre-treatment of test solution. In this study, it was confirmed that the water solubility of test item was more than the upper limit (50 g/L). Therefore, only three test solutions were prepared. The prepared test solutions were agitated at 30 °C with the constant temperature shaking water bath after stirring for one hour at room temperature. After 2 days, three test solutions were taken out from the constant temperature shaking water bath and equilibrated for 24 hours at the test temperature using the low constant temperature water bath. These solutions were pre-treated, pH adjustment and centrifugation, and analysed using High Performance Liquid Chromatography (HPLC). The water solubility of the test item was determined to be >50 g/L at 20 °C.

Description of key information

The water solubility of the test item was determined to be >50 g/L at 20°C.

Key value for chemical safety assessment

Water solubility:

50 g/L

at the temperature of:

20 °C