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EC number: 263-961-7
CAS number: 63149-24-6
cl – confidence limit.
The objectiveofthe study was to evaluate V173671 for its
ability to generate toxic effects in Raphidocelis subcapitata during
an exposure period of 72 hours and, if possible, to determine the NOEC,
EC10, EC20and EC50for both inhibition
of growth rate and inhibition of yield.
The study procedures described in this report were based on the
OECD guideline No. 201, 2006; Annex 5 corrected 28 July 2011.
The batch of V173671 tested was a light blue powder with a purity of >99
mol% and completely soluble in test medium at the concentrations tested.
A final test was performed based on the results of a preceding combined
limit/range-finding test.Six replicates of exponentially growing
algal cultures were exposed to an untreated control, whereas three
replicates per group were exposed to 0.32, 1.0, 3.2, 10, 32 and
100 mg/L. The initial algal cell density was 104cells/mL.
The total exposure period was 72 hours and samples for analytical
confirmation of exposure concentrations were taken at the start, after
24 and 72 hours of exposure.
Samples taken from all test concentrations and the control were
analysed. The measured concentrationsat the start of the testwere
0.13, 0.66, 2.4, 7.9, 29 and 93 mg/L, respectively. During the exposure
period, the concentrations changed to 123, 100, 103, 92, 66 and 36% of
initial, respectively, at the end of the test. Based on these results,
the Time Weighted Average (TWA) concentrations were calculated and used
to express effect parameters.
Statistically significant inhibition of growth rates and yield with
V173671 was only found at the highest test concentration of 56 mg/L
(nominal: 100 mg/L). The NOEC based on statistical significance was thus
determined to be 24 mg/L for both effect parameters.
The study met the acceptability criteria prescribed by the study
plan and was considered valid.
The effect parameters obtained in this study are summarized in the
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