Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 263-961-7
CAS number: 63149-24-6
The objective of this study was to determine the
potential of V173671 and/or its metabolites to induce
reverse mutations at the histidine locus in several strains
of Salmonella typhimurium (S. typhimurium;
TA98, TA100, TA1535, and TA1537), and at the tryptophan
locus of Escherichia coli (E. coli) strain WP2uvrA
in the presence or absence of an exogenous mammalian
metabolic activation system (S9).
The study procedures described in this report were based on
the most recent OECD 471 (1997) and EC 440/2008 guidelines.
Batch V173671/DW (= v173671/E3A) of V173671 was a
light blue powder. The vehicle of the test item was dimethyl
In the dose-range finding study, the test item was
tested up to concentrations of 5000 µg/plate in the strains
TA100 and WP2uvrAin the absence and
presence of 5% (v/v)
S9-mix. In the first mutation experiment, the test item was again tested
up to concentrations of 5000 µg/plate in the strains TA1535,
TA1537 and TA98 in the absence and presence of 5% (v/v)
S9-mix. In a follow-up experiment of the assay with
additional parameters, the test item was tested at a
concentration range of 492 to 5000 µg/plate in the absence
and presence of 10% (v/v) S9-mix in the tester strains
TA1535, TA1537, TA98, TA100 and WP2uvrA. In
all three experiments the test item did not precipitate on
the plates at this dose level. The bacterial background lawn
was not reduced at any of the concentrations tested (i.e. no
cytotoxicity) and no biologically relevant decrease in the
number of revertants was observed.
V173671 did not induce a significant dose-related increase
in the number of revertant (His+) colonies in any
of the four tester strains (TA1535, TA1537, TA98 and TA100)
nor in the number of revertant (Trp+) colonies in
the tester strain WP2uvrA, both in the
absence and presence of S9-metabolic activation. These
results were confirmed in a follow-up experiment.
The negative and strain-specific positive control values
were within the laboratory historical control data ranges
indicating that the test conditions were adequate and that
the metabolic activation system functioned properly.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again