Registration Dossier
Registration Dossier
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EC number: 701-303-7 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Sucrose, ethoxylated and propoxylated was tested according to OECD Guideline 471 (Bacterial reverse mutation assay, BASF SE 2011). There were negative findings both with and without metabolic activation.
The results from a mammalian point mutation assay have been 'read across' from 2, 2', 2''-nitrilotriethanol, propoxylated (ISOPA 2009). They are negative.
The results of chromosome abberation assays have been 'read across' from 2,2',2''-nitrilotriethanol, propoxylated, glycerol, propoxylated and D-glucitol, propoxylated (ISOPA, 2005). All indicated assay are negative.
For more information on the read across rationale see report from Paul Illing Consultancy Services Ltd and Marlin Consultancy (Illing and Barratt, 2007, revised 2009). The report identifies that 2, 2', 2''-nitrilotriethanol, propoxylated is the most bioavailable of the polyols linked by an ether group. Since appropriate read-across data are available, no further testing on sucrose, propoxylated is warranted. For further details concerning the groupings consult Illing and Barratt (2007, revised 2009).
Short description of key information:
Three in vitro mutagenicity tests using different end points were all negative. Therefore further testing is not required.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Substance does not meet criteria for classification.
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